ABCG2 modulates chlorothiazide permeability in vitro – characterization of the interaction
We are showing that chlorothiazide, a diuretic, is an ABCG2 substrate. It is a Biopharmaceutics Classification System/Biopharmaceutics Drug Distribution and Classification System (BCS/BDDCS) Class IV drug with low bioavailability. Therefore, we tested if chlorothiazide interacts with major apic...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2012
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| Sorozat: | DRUG METABOLISM AND PHARMACOKINETICS
27 No. 3 |
| Tárgyszavak: | |
| doi: | 10.2133/dmpk.DMPK-11-NT-068 |
| mtmt: | 1765884 |
| Online Access: | https://publikacio.ppke.hu/2382 |