Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases fitness in the presence of fluconazole, but the underlying molecular mechanism is not understood....

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Bibliographic Details
Main Authors: Weil Tobias
Santamaria Rodrigo
Lee Wanseon
Rung Johan
Tocci Noemi
Abbey Darren
Bezerra Ana R.
Carreto Laura
Moura Gabriela R.
Bayes Monica
Gut Ivo G.
Csikász-Nagy Attila
Cavalieri Duccio
Berman Judith
Santos Manuel A. S.
Format: Article
Published: 2017
Series:mSPHERE 2 No. 4
Subjects:
mtmt:30439623
Online Access:https://publikacio.ppke.hu/1684