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20260326134514.0 |
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260326s2024 hu o 000 Angol d |
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|a 1661-6596
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|a 10.3390/ijms25031865
|2 doi
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|a 34563187
|2 mtmt
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|a PPKE Publikáció Repozitórium
|b hun
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|a Angol
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|a Tóth Eszter
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| 245 |
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|a Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss
|b Functional Relevance and Diagnostic Value
|c Tóth Eszter
|h [elektronikus dokumentum]
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|c 2024
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|a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|v 25 No. 3
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| 520 |
3 |
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|a Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pathophysiology of RPL is incomplete, and thus, reliable diagnostic/preventive tools are not yet available. Here, we aimed to define the diagnostic value of three placental proteins for RPL: human chorionic gonadotropin free beta-subunit (free-β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF). Blood samples were collected from women with RPL (n = 14) and controls undergoing elective termination of pregnancy (n = 30) at the time of surgery. Maternal serum protein concentrations were measured by BRAHMS KRYPTOR Analyzer. Daily multiple of median (dMoM) values were calculated for gestational age-specific normalization. To obtain classifiers, logistic regression analysis was performed, and ROC curves were calculated. There were differences in changes of maternal serum protein concentrations with advancing healthy gestation. Between 6 and 13 weeks, women with RPL had lower concentrations and dMoMs of free β-hCG, PAPP-A, and PlGF than controls. PAPP-A dMoM had the best discriminative properties (AUC = 0.880). Between 9 and 13 weeks, discriminative properties of all protein dMoMs were excellent (free β-hCG: AUC = 0.975; PAPP-A: AUC = 0.998; PlGF: AUC = 0.924). In conclusion, free-β-hCG and PAPP-A are valuable biomarkers for RPL, especially between 9 and 13 weeks. Their decreased concentrations indicate the deterioration of placental functions, while lower PlGF levels indicate problems with placental angiogenesis after 9 weeks.
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|a Szerves kémia
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| 650 |
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4 |
|a Szervetlen szintézis
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4 |
|a Elméleti és számítási kémia
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4 |
|a Molekuláris biológia
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1 |
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|a Györffy Dániel
|e aut
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1 |
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|a Posta Máté
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|a Hupuczi Petronella
|e aut
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|a Balogh Andrea
|e aut
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1 |
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|a Szalai Gábor
|e aut
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1 |
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|a Orosz Gergő Balázs
|e aut
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1 |
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|a Orosz László
|e aut
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1 |
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|a Szilágyi András
|e aut
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1 |
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|a Oravecz Orsolya
|e aut
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| 700 |
1 |
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|a Veress Lajos
|e aut
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1 |
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|a Nagy Sándor
|e aut
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1 |
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|a Török Olga
|e aut
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1 |
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|a Murthi Padma
|e aut
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1 |
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|a Erez Offer
|e aut
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1 |
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|a Papp Zoltán
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|a Ács Nándor
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|a Than Nándor Gábor
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|u https://publikacio.ppke.hu/id/eprint/3579/1/ijms-25-01865.pdf
|z Dokumentum-elérés
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